Which cytokine signaling mode travels through the circulatory system to distant cells?

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Multiple Choice

Which cytokine signaling mode travels through the circulatory system to distant cells?

Explanation:
Endocrine signaling is the mode where signals are released into the bloodstream and travel through the circulatory system to distant target cells that have the appropriate receptors. This fits the idea of a signal moving through blood to affect cells far away, coordinating responses throughout the body. In contrast, paracrine signaling acts on nearby cells in the local environment, autocrine signaling affects the secreting cell itself, and juxtacrine signaling requires direct cell-to-cell contact via membrane-bound signals, not circulation.

Endocrine signaling is the mode where signals are released into the bloodstream and travel through the circulatory system to distant target cells that have the appropriate receptors. This fits the idea of a signal moving through blood to affect cells far away, coordinating responses throughout the body. In contrast, paracrine signaling acts on nearby cells in the local environment, autocrine signaling affects the secreting cell itself, and juxtacrine signaling requires direct cell-to-cell contact via membrane-bound signals, not circulation.

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